| Name | Meaning | Gender | Origin |
|---|
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Serenity | Peacefulness | Female | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Shelby | A place where willows grow | Female | American English |
| Shorty | Of less than average size | Unisex | English |
| Sierra | Mountain range | Female | Spanish |
| Silver | Silver (the metal or colour) | Male | English |
| Simba | Lion | Female | Swahili |
| Simon | Listening | Male | Hebrew |
| Skippy | Master of a Ship | Unisex | American English |
| Slim | Slender in proportion to height. | Unisex | English |
| Smiley | | Unisex | Hebrew |
| Snoopy | | Unisex | Hebrew |
| Snowball | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Squirt | Slang for a small person | Unisex | English |
| Steve | Crown | Male | Greek |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunny | Filled with sunlight | Male | English |
| Sweetie | Sweetheart. | Unisex | English |
| Taffy | Beloved | Female | Welsh |
| Tate | "Pleasant And Bright."Some Variants Are Tait, Taite, And Tayte. | Female | English |
| Teddy | Gift of God | Male | Greek |
| Tiny | Extremely small | Unisex | English |
| Toby | God is good | Unisex | Hebrew |
| Tootsie | A girl or young woman. | Unisex | English |
| Tucker | Someone who folds cloth | Male | English |
| Tulip | | Unisex | Hebrew |