| Name | Meaning | Gender | Origin |
|---|
| Snuggles | To curl up closely, cuddle | Unisex | English |
| Sofia | Wisdom | Female | Greek |
| Sophia | Wisdom | Female | Greek |
| Sophie | Wisdom | Female | Greek |
| Sparkle | To shine with animation | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprinkles | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Star | Star | Female | Latin |
| Starburst | | Unisex | Hebrew |
| Starla | Star | Unisex | Latin |
| Starr | Star | Female | Latin |
| Steffi | Crown | Female | Greek |
| Stella | Star | Female | Latin |
| Stitch | After the character in the Lilo And Stitch cartoon | Unisex | English |
| Storm | Violent weather | Female | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suki | To like | Female | Japanese |
| Sunshine | Light from the sun | Unisex | English |
| Sweetie | Sweetheart. | Unisex | English |
| Sydney | Wide meadow | Female | English |
| Taboo | | Unisex | Hebrew |
| Taffy | Beloved | Female | Welsh |
| Tallulah | Abundance, lady, princess | Female | Gaelic |
| Tasha | (Christ's) birthday | Female | Latin |
| Ted | Gift of God | Male | Greek |
| Teddy | Gift of God | Male | Greek |
| Tess | Harvester | Female | Greek |
| Tessa | Harvester | Female | Greek |
| Tiara | A three-tiered crown | Female | English |