| Name | Meaning | Gender | Origin |
|---|
| Shady | | Unisex | Hebrew |
| Shae | Supplanter | Unisex | Hebrew |
| Shaggy | Bushy and matted (hair), unkempt. | Unisex | English |
| Shaka | | Unisex | Hebrew |
| Shark | | Unisex | Hebrew |
| Shay | Supplanter | Male | Hebrew |
| Shepherd | One who guards sheeps | Male | English |
| Sherman | One who shears cloth | Male | English |
| Slash | | Unisex | Hebrew |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snake | | Unisex | Hebrew |
| Sniper | A skilled shooter who spots targets from a concealed place. | Unisex | English |
| Socrates | Uncertain meaning | Male | Greek |
| Sol | Peace | Male | Hebrew |
| Spartacus | From the city of Sparta | Unisex | English |
| Spider | An eight legged insect | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Stetson | Son of Stephen | Male | English |
| Sticky | | Unisex | Hebrew |
| Stone | Stone | Male | English |
| Stormy | Violent weather | Unisex | English |
| Sutton | Town on the south | Male | English |
| Sylvester | A forest | Male | Latin |
| Talli | Dew of God | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tanner | Tanner | Male | English |
| Tarzan | White skin | Unisex | Literary |
| T-bone | A thick steak containing a T shaped bone. | Unisex | English |
| Tequila | An alcoholic liquor distilled from mescal. | Unisex | English |