| Name | Meaning | Gender | Origin |
|---|
| Speedy | Rapid motion, swift. | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Squeaker | | Unisex | Hebrew |
| Squeakers | | Unisex | Hebrew |
| Squeaky | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Sterling | Little star - stellar | Male | English |
| Sticky | | Unisex | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunny | Filled with sunlight | Male | English |
| Susannah | Lily | Female | Hebrew |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | English |
| Taffy | Beloved | Female | Welsh |
| Tallulah | Abundance, lady, princess | Female | Gaelic |
| Tansy | Immortal | Male | Greek |
| Tatum | Tate's homestead | Female | English |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Teagan | Little poet | Female | Gaelic |
| Teeny | | Unisex | Hebrew |
| Thumper | To walk with heavy steps | Unisex | English |
| Tinkerbell | | Unisex | Hebrew |
| Tino | From the god Mars | Male | Latin |
| Tiny | Extremely small | Unisex | English |
| Tomkin | Twin | Male | Aramaic |
| Toni | Abbreviation Of Antonia And Antoinette. | Female | Latin |
| Tony | Derived From Victoria Triumphant. | Male | Latin |
| Tonya | Feminine Form Of Anthony | Female | Latin |
| Tootsie | A girl or young woman. | Unisex | English |
| Topsy | On top | Unisex | English |