| Name | Meaning | Gender | Origin |
|---|
| Rascal | One that is playfully mischievous | Unisex | English |
| Raven | Raven | Male | English |
| Rio | River | Male | Spanish |
| Ripley | Separate | Male | English |
| Rocky | Battle cry | Male | Germanic |
| Ronin | Little seal | Male | Gaelic |
| Roscoe | Roe deer wood | Male | Norse |
| Sabre | | Unisex | Hebrew |
| Sadie | Princess | Female | Hebrew |
| Safari | | Unisex | Hebrew |
| Salem | Secure, peace | Unisex | Arabic |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Seamus | Form Of James Supplanter. | Male | English |
| Shadow | Shadow | Unisex | English |
| Shasta | Name of a Native American tribe | Female | Native American |
| Shelby | A place where willows grow | Female | American English |
| Skittles | | Unisex | Hebrew |
| Skye | Cloud | Male | Norse |
| Smoky | | Unisex | Hebrew |
| Smudge | A blotch or smear | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Sooty | Covered with soot | Unisex | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sputnik | | Unisex | Hebrew |
| Squeak | | Unisex | Hebrew |
| Sunshine | Light from the sun | Unisex | English |
| Taboo | | Unisex | Hebrew |
| Talia | Dew of God | Female | Hebrew |
| Tango | | Unisex | Hebrew |
| Tequila | An alcoholic liquor distilled from mescal. | Unisex | English |