| Name | Meaning | Gender | Origin |
|---|
| Sparkle | To shine with animation | Unisex | English |
| Sparky | Animated, lively. | Unisex | English |
| Spartacus | From the city of Sparta | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Sphinx | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spinner | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | English |
| Spud | Slang for potato. | Unisex | English |
| Squeaky | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | English |
| Star | Star | Female | Latin |
| Stardust | | Unisex | Hebrew |
| Starlight | | Unisex | Hebrew |
| Stella | Star | Female | Latin |
| Sterling | Little star - stellar | Male | English |
| Stetson | Son of Stephen | Male | English |
| Steve | Crown | Male | Greek |
| Stevie | Crown | Unisex | Greek |
| Storm | Violent weather | Female | English |
| Stumpy | A short, thickset person | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunday | 7th day of the week | Unisex | English |
| Sunny | Filled with sunlight | Male | English |
| Sunshine | Light from the sun | Unisex | English |
| Suzie | Lily | Unisex | Hebrew |
| Sweetie | Sweetheart. | Unisex | English |
| Sylvia | Wooded | Female | Latin |