| Name | Meaning | Gender | Origin |
|---|
| Reno | Ruler with counsel | Unisex | Germanic |
| River | River | Unisex | English |
| Rocket | To move swiftly and powerfully | Unisex | English |
| Roxy | Star | Female | Persian |
| Sampson | Sun | Unisex | Hebrew |
| Sarge | Noncommissioned Army or Air Force rank | Unisex | English |
| Sasha | Defending men | Unisex | Greek |
| Sasquatch | Has extra toes and hence is a bigfoot | Unisex | English |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Serena | Composed | Female | Latin |
| Shawnee | Tribal name | Female | Native American |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sierra | Mountain range | Female | Spanish |
| Simba | Lion | Female | Swahili |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Slate | | Unisex | Hebrew |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snowball | | Unisex | Hebrew |
| Snowy | Covered with snow | Female | English |
| Sonya | Wisdom | Female | Greek |
| Spidey | | Unisex | Hebrew |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Sprite | Lemonade flavored soft drink. | Unisex | English |
| Storm | Violent weather | Female | English |
| Stormy | Violent weather | Unisex | English |
| Tahoe | Edge of the lake | Unisex | Native American |
| Tango | | Unisex | Hebrew |
| Tank | A large metal container. A heavily armed combat vehicle | Unisex | English |
| Tasha | (Christ's) birthday | Female | Latin |