| Name | Meaning | Gender | Origin |
|---|
| Sadie | Princess | Female | Hebrew |
| Sally | Princess | Female | Hebrew |
| Sassy | Lively and spirited | Unisex | English |
| Sawyer | One who saws wood | Male | English |
| Scooby | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Serena | Composed | Female | Latin |
| Shamus | Supplanter | Male | Hebrew |
| Sharman | One who shears cloth | Female | English |
| Shayna | Beautiful | Female | Yiddish |
| Shirley | Bright grassland | Female | English |
| Simba | Lion | Female | Swahili |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Spartacus | From the city of Sparta | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Star | Star | Female | Latin |
| Stella | Star | Female | Latin |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Suzie | Lily | Unisex | Hebrew |
| Sylvia | Wooded | Female | Latin |
| Talia | Dew of God | Female | Hebrew |
| Tango | | Unisex | Hebrew |
| Taz | Wild Animal, Thrid Born | Unisex | American |
| Tequila | An alcoholic liquor distilled from mescal. | Unisex | English |
| Tiger | Tiger | Unisex | English |
| Tiki | Maori figure representing an ancestor. A wooden or stone image of a Polynesian god. | Unisex | English |
| Tilly | Powerful battler | Unisex | Germanic |