| Name | Meaning | Gender | Origin |
|---|
| Rocky | Battle cry | Male | Germanic |
| Roman | Roman | Unisex | Latin |
| Roxie | Star | Unisex | Persian |
| Saber | Patient | Male | English |
| Sadie | Princess | Female | Hebrew |
| Sargent | A Squire | Male | English |
| Sasha | Defending men | Unisex | Greek |
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Shea | Hawklike - graceful, free, courageous | Male | Gaelic |
| Shiloh | Gift for him | Unisex | Hebrew |
| Skittles | | Unisex | Hebrew |
| Sky | Sky | Unisex | Norse |
| Skyla | The sky | Female | American English |
| Skylar | Guarded | Female | Dutch |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Unisex | English |
| Snickers | A brand of candy bar. | Unisex | English |
| Snoopy | | Unisex | Hebrew |
| Sonny | Son | Male | English |
| Sophie | Wisdom | Female | Greek |
| Speckles | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Unisex | English |
| Spot | After Data's cat on Star Trek: The Next Generation | Unisex | English |
| Sprinkles | | Unisex | Hebrew |
| Stella | Star | Female | Latin |
| Stormy | Violent weather | Unisex | English |
| Streak | | Unisex | Hebrew |