| Name | Meaning | Gender | Origin |
|---|
| Sandy | Defending men | Male | Greek |
| Sapphire | Beautiful jewel | Female | Greek |
| Sasha | Defending men | Unisex | Greek |
| Sassy | Lively and spirited | Unisex | English |
| Satan | The Devil and adversary of God | Unisex | English |
| Satin | Amber | Female | Armenian |
| Scarlet | Scarlet | Female | English |
| Scout | Observer | Unisex | American English |
| Shadow | Shadow | Unisex | English |
| Sheba | Daughter of an oath | Female | Hebrew |
| Sheila | Blind | Female | Latin |
| Shelby | A place where willows grow | Female | American English |
| Simba | Lion | Female | Swahili |
| Skye | Cloud | Male | Norse |
| Smoky | | Unisex | Hebrew |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Storm | Violent weather | Female | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sully | Keen eye | Male | Gaelic |
| Sydney | Wide meadow | Female | English |
| Talia | Dew of God | Female | Hebrew |
| Talon | A claw | Male | English |
| Tasha | (Christ's) birthday | Female | Latin |
| Teal | The Bird Teal: Also The Blue-Green Color. | Unisex | English |
| Teddy | Gift of God | Male | Greek |
| Tempest | Storm | Female | English |
| Toby | God is good | Unisex | Hebrew |
| Trouble | A cause of disturbance or difficulty. | Unisex | English |