| Name | Meaning | Gender | Origin |
|---|
| Sheba | Daughter of an oath | Female | Hebrew |
| Shirley | Bright grassland | Female | English |
| Sienna | Reddish orange-brown | Female | Italian |
| Sierra | Mountain range | Female | Spanish |
| Silvana | Of the forest | Female | Latin |
| Silver | Silver (the metal or colour) | Male | English |
| Simba | Lion | Female | Swahili |
| Simone | Listening | Female | Hebrew |
| Slate | | Unisex | Hebrew |
| Smoky | | Unisex | Hebrew |
| Snappy | cleverly concise; neat | Both | Hebrew |
| Soda | A carbonated water. | Unisex | English |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | English |
| Sophie | Wisdom | Female | Greek |
| Sparky | Animated, lively. | Unisex | English |
| Speedy | Rapid motion, swift. | Unisex | English |
| Spencer | Someone who gives out goods | Male | French |
| Spider | An eight legged insect | Unisex | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | English |
| Spud | Slang for potato. | Unisex | English |
| Spunky | Spirited, plucky. | Unisex | English |
| Stretch | To extend to full length. | Unisex | English |
| Strider | | Unisex | Hebrew |
| Styx | Myth Name (A River Of The Underworld) | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | English |
| Sunshine | Light from the sun | Unisex | English |
| Sydney | Wide meadow | Female | English |
| Talbot | Messenger of destruction | Male | English |
| Tallulah | Abundance, lady, princess | Female | Gaelic |
| Tammy | Twin | Female | Aramaic |